ZYMEWORKS INC (ZYME)
Health Care · Antibody therapeutics and bispecific antibody-drug conjugate development · NASDAQ
A biotech company pioneering multispecific antibodies and ADCs for cancer and autoimmune disease, monetizing through a partnership-driven royalty aggregation model while advancing an internal pipeline.
What ZYMEWORKS INC does
Zymeworks is a global biotechnology company that develops novel biotherapeutics targeting cancer, inflammation, and autoimmune disease through proprietary multispecific antibody therapeutics (MSATs) and antibody-drug conjugate (ADC) platforms. The company executes an asset and royalty aggregation strategy, managing a portfolio of licensed healthcare assets and product candidates while pursuing partnerships to generate milestone and royalty cash flows. Its first approved product, zanidatamab (Ziihera), a bispecific antibody for HER2-positive biliary tract cancer, is commercialized through strategic partners BeOne Medicines and Jazz Pharmaceuticals, providing near-term milestone and royalty revenues.
Themes: ["Bispecific antibodies / multispecific therapeutics","Oncology / HER2-positive cancer","Antibody-drug conjugates (ADCs)","Inflammation and autoimmune disease","Royalty aggregation / partnership-based monetization","Early-stage drug development"]
Fundamentals
- Price$27.07 as of 2026-07-09 close
- Market cap$2.0B as of 2026-07-10
- 1-year return+99.5% as of 2026-07-09 close
- Net margin-126.3% as of 2026-07-10
- ROE-37.8% as of 2026-07-10
- Debt / equity0.00 as of 2026-07-10
- Revenue growth (YoY)+3.3% as of 2026-07-10
- Revenue CAGR (3y)-36.4% SEC XBRL
- Beta1.14 as of 2026-07-10
Key risks (from latest filing)
["Regulatory and clinical development uncertainty: the company's business depends on regulatory approval and successful commercialization of product candidates, with no guarantee of timing or success; reliance on strategic partners for development and commercialization creates dependency on third-party execution and decisions","Cash burn and funding dependency: the company is unprofitable with an accumulated deficit of $1.07 billion and negative net margins of -126%, requiring continued capital from public markets and milestone/royalty revenues to fund operations","Partnership execution risk: the company's near-term cash generation depends on BeOne and Jazz successfully commercializing zanidatamab and achieving clinical and regulatory milestones for other partnered programs"]
Competitors & peers
- Amgen (AMGN)
- Regeneron Pharmaceuticals (REGN)
- Genmab (GMAB)
- Incyte (INCY)
- Alnylam Pharmaceuticals (ALNY)
- Morphotek (subsidiary of Incyte)
- ADC Therapeutics (ADCT)
Fundamentals: Finnhub, as of 2026-07-10. Filings: SEC EDGAR. Prices are delayed daily-close data.
Last updated 2026-07-09.
Informational only — NOT financial advice. All figures are delayed daily-close data from SEC EDGAR & Finnhub, shown with their as-of date.