ISRG vs VRTX
ISRG: Intuitive Surgical designs and manufactures robotic-assisted surgical platforms that enable minimally invasive procedures with superior precision and clinician control. VRTX: Vertex Pharmaceuticals develops transformative medicines for serious genetic diseases, with a dominant pipeline anchored in cystic fibrosis treatments and groundbreaking gene-editing therapies for blood disorders and pain.
Side-by-side fundamentals
| Metric | ISRG | VRTX | Edge |
|---|---|---|---|
| Price as of 2026-07-09 close | $411.55 | $498.43 | |
| Market cap as of 2026-07-10 | $145.7B | $130.3B | |
| P/E as of 2026-07-10 | 48.90 | 30.05 | VRTX lower |
| PEG as of 2026-07-10 | 2.97 | 2.31 | VRTX lower |
| Net margin as of 2026-07-10 | +28.1% | +35.5% | VRTX higher |
| Gross margin as of 2026-07-10 | +66.3% | +86.2% | VRTX higher |
| Operating margin as of 2026-07-10 | +30.4% | +38.3% | VRTX higher |
| ROE as of 2026-07-10 | +17.0% | +23.9% | VRTX higher |
| ROA as of 2026-07-10 | +14.9% | +17.2% | VRTX higher |
| Debt / equity as of 2026-07-10 | 0.00 | 0.01 | ISRG lower |
| Revenue growth (YoY) as of 2026-07-10 | +21.4% | +10.1% | ISRG higher |
| Revenue CAGR (3y) SEC XBRL | +17.4% | +10.4% | ISRG higher |
| Beta as of 2026-07-10 | 1.46 | 0.29 | |
| 1-year return as of 2026-07-09 close | -22.1% | +6.9% | VRTX higher |
Fundamentals: Finnhub, as of 2026-07-10. Filings: SEC EDGAR. Prices are delayed daily-close data.
Last updated 2026-07-09.
Informational only — NOT financial advice. All figures are delayed daily-close data from SEC EDGAR & Finnhub, shown with their as-of date; "Edge" cells are a pure numeric comparison, not a recommendation.