IONS vs ZVRA
IONS: Pioneer in RNA-targeted antisense medicines with seven commercialized products and expanding late-stage pipeline across rare neurological and cardiometabolic diseases, now executing independent U.S. launches while generating royalty revenue from major pharma partnerships. ZVRA: Zevra brings life-changing therapies to ultra-rare neurodegenerative and metabolic diseases, with FDA-approved MIPLYFFA for Niemann-Pick disease type C now generating revenue and a pipeline of clinical candidates addressing severe unmet needs.
Side-by-side fundamentals
| Metric | IONS | ZVRA | Edge |
|---|---|---|---|
| Price as of 2026-07-22 close | $54.01 | $12.14 | |
| Market cap as of 2026-07-23 | $8.8B | $762M | |
| P/E as of 2026-07-23 | n/a | 6.13 | |
| Net margin as of 2026-07-23 | -30.9% | +101.6% | ZVRA higher |
| Gross margin as of 2026-07-23 | +98.3% | +97.9% | IONS higher |
| Operating margin as of 2026-07-23 | -33.3% | -4.4% | ZVRA higher |
| ROE as of 2026-07-23 | -58.7% | +81.3% | ZVRA higher |
| ROA as of 2026-07-23 | -10.1% | +45.6% | ZVRA higher |
| Debt / equity as of 2026-07-23 | 4.76 | 0.00 | ZVRA lower |
| Revenue growth (YoY) as of 2026-07-23 | +47.4% | +201.3% | ZVRA higher |
| Revenue CAGR (3y) SEC XBRL | +17.1% | n/a | |
| Beta as of 2026-07-23 | 0.38 | 0.90 | |
| 1-year return as of 2026-07-22 close | +28.5% | +4.8% | IONS higher |
Fundamentals: Finnhub, as of 2026-07-23. Filings: SEC EDGAR. Prices are delayed daily-close data.
Last updated 2026-07-22.
Informational only — NOT financial advice. All figures are delayed daily-close data from SEC EDGAR & Finnhub, shown with their as-of date; "Edge" cells are a pure numeric comparison, not a recommendation.