AGIO vs VRTX
AGIO: Agios Pharmaceuticals is a rare disease-focused biopharmaceutical company advancing a pipeline of novel hematology and genetic disorder therapies, anchored by its pyruvate kinase activator, mitapivat. VRTX: Vertex is a leader in biotechnology primarily recognized for its dominance in cystic fibrosis therapy and its emerging pipeline of gene-editing treatments and non-opioid pain relief.
Side-by-side fundamentals
| Metric | AGIO | VRTX | Edge |
|---|---|---|---|
| Price as of 2026-10-08 close | $31.92 | $503.25 | |
| Market cap | $1.9B | $127.6B | |
| P/E as of 2026-10-08 | n/a | 29.28 | |
| Net margin FY2025, SEC XBRL | -764.0% | +32.9% | VRTX higher |
| Operating margin FY2025, SEC XBRL | -873.9% | +34.8% | VRTX higher |
| ROE FY2025, SEC XBRL | -34.6% | +21.2% | VRTX higher |
| ROA FY2025, SEC XBRL | -31.8% | +15.4% | VRTX higher |
| Debt / equity as of 2026-09-03 | 0.00 | 0.00 | Tie |
| Revenue growth (YoY) as of 2026-09-03 | +140.6% | +10.2% | AGIO higher |
| Revenue CAGR (3y) SEC XBRL | +56.0% | +10.4% | AGIO higher |
| Dividend streak (yrs) SEC XBRL | 0 | 0 | Tie |
| Beta as of 2026-09-03 | 1.02 | 0.47 | |
| 1-year return as of 2026-10-08 close | -25.1% | +19.5% | VRTX higher |
Fundamentals: SEC XBRL company filings for the figures marked with a fiscal year, and market data, as of 2026-09-03 for the rest. Filings: SEC EDGAR. Prices are delayed daily-close data.
Last updated 2026-10-08.
Informational only — NOT financial advice. All figures are delayed daily-close data from SEC EDGAR & market data, shown with their as-of date; "Edge" cells are a pure numeric comparison, not a recommendation.