AGIO vs VRTX
AGIO: Agios Pharmaceuticals is a rare disease-focused biopharmaceutical company advancing a pipeline of novel hematology and genetic disorder therapies, anchored by its pyruvate kinase activator, mitapivat. VRTX: Vertex Pharmaceuticals develops transformative medicines for serious genetic diseases, with a dominant pipeline anchored in cystic fibrosis treatments and groundbreaking gene-editing therapies for blood disorders and pain.
Side-by-side fundamentals
| Metric | AGIO | VRTX | Edge |
|---|---|---|---|
| Price as of 2026-07-31 close | $30.02 | $477.10 | |
| Market cap as of 2026-08-03 | $1.8B | $121.1B | |
| P/E as of 2026-08-03 | n/a | 28.29 | |
| PEG as of 2026-08-03 | n/a | 2.28 | |
| Net margin as of 2026-08-03 | -418.2% | +35.5% | VRTX higher |
| Gross margin as of 2026-08-03 | +92.0% | +86.2% | AGIO higher |
| Operating margin as of 2026-08-03 | -466.8% | +38.3% | VRTX higher |
| ROE as of 2026-08-03 | -35.7% | +23.9% | VRTX higher |
| ROA as of 2026-08-03 | -33.1% | +17.2% | VRTX higher |
| Debt / equity as of 2026-08-03 | 0.00 | 0.01 | AGIO lower |
| Revenue growth (YoY) as of 2026-08-03 | +140.6% | +10.1% | AGIO higher |
| Revenue CAGR (3y) SEC XBRL | +56.0% | +10.4% | AGIO higher |
| Beta as of 2026-08-03 | 1.04 | 0.48 | |
| 1-year return as of 2026-07-31 close | -19.3% | +4.4% | VRTX higher |
Fundamentals: market data, as of 2026-08-03. Filings: SEC EDGAR. Prices are delayed daily-close data.
Last updated 2026-07-31.
Informational only — NOT financial advice. All figures are delayed daily-close data from SEC EDGAR & market data, shown with their as-of date; "Edge" cells are a pure numeric comparison, not a recommendation.