AMGN vs SEPN
AMGN: Amgen is a leading biotechnology firm dedicated to developing innovative human therapeutics to address critical unmet needs in areas like oncology, inflammation, and cardiovascular disease. SEPN: Septerna is a biotechnology company pioneering a new approach to unlock the therapeutic potential of G protein-coupled receptors (GPCRs) through oral small molecule drug discovery.
Side-by-side fundamentals
| Metric | AMGN | SEPN | Edge |
|---|---|---|---|
| Price as of 2026-10-20 close | $438.94 | $39.35 | |
| Market cap | $237.3B | $1.8B | |
| P/E as of 2026-10-20 | 27.26 | n/a | |
| Net margin FY2025, SEC XBRL | +21.0% | -106.4% | AMGN higher |
| Operating margin FY2025, SEC XBRL | +24.7% | -148.6% | AMGN higher |
| ROE FY2025, SEC XBRL | +89.1% | -12.8% | AMGN higher |
| ROA FY2025, SEC XBRL | +8.5% | -8.2% | AMGN higher |
| Debt / equity filed borrowings, leases excl., balance sheet 2026-06-30 | 4.90 | n/a | |
| Revenue growth (YoY) FY2025, SEC XBRL | +9.9% | +4174.5% | SEPN higher |
| Revenue CAGR (3y) SEC XBRL | +11.8% | +1644.5% | SEPN higher |
| Dividend yield as of 2026-09-03 | +2.6% | n/a | |
| Dividend streak (yrs) SEC XBRL | 15 | 0 | AMGN higher |
| Beta as of 2026-09-03 | 0.41 | 1.24 | |
| 1-year return as of 2026-10-20 close | +44.7% | +75.4% | SEPN higher |
Fundamentals: SEC XBRL company filings for the figures marked with a fiscal year, and market data, as of 2026-09-03 for the rest. Filings: SEC EDGAR. Prices are delayed daily-close data.
Last updated 2026-10-20.
Informational only — NOT financial advice. All figures are delayed daily-close data from SEC EDGAR & market data, shown with their as-of date; "Edge" cells are a pure numeric comparison, not a recommendation.