BIIB vs IONS
BIIB: A pioneer in neuroscience and immunology, Biogen is a major biotechnology company focused on addressing high-unmet medical needs in complex diseases like Alzheimer’s, Multiple Sclerosis, and SMA. IONS: Ionis Pharmaceuticals is a pioneer in RNA-targeted therapies, transitioning into a commercial-stage biotech with a pipeline focused on neurology and cardiometabolic diseases.
Side-by-side fundamentals
| Metric | BIIB | IONS | Edge |
|---|---|---|---|
| Price as of 2026-10-08 close | $218.43 | $43.30 | |
| Market cap | $32.2B | $7.2B | |
| P/E as of 2026-10-08 | 38.68 | n/a | |
| Net margin FY2025, SEC XBRL | +13.1% | -40.4% | BIIB higher |
| Operating margin | +25.9% | -40.4% | BIIB higher |
| ROE FY2025, SEC XBRL | +7.1% | -78.0% | BIIB higher |
| ROA FY2025, SEC XBRL | +4.4% | -10.8% | BIIB higher |
| Debt / equity as of 2026-09-03 | 0.43 | 4.35 | BIIB lower |
| Revenue growth (YoY) as of 2026-09-03 | +0.3% | -7.5% | BIIB higher |
| Revenue CAGR (3y) SEC XBRL | -0.9% | +17.1% | IONS higher |
| Dividend streak (yrs) SEC XBRL | 0 | 0 | Tie |
| Beta as of 2026-09-03 | 0.51 | 0.70 | |
| 1-year return as of 2026-10-08 close | +44.7% | -38.1% | BIIB higher |
Fundamentals: SEC XBRL company filings for the figures marked with a fiscal year, and market data, as of 2026-09-03 for the rest. Filings: SEC EDGAR. Prices are delayed daily-close data.
Last updated 2026-10-08.
Informational only — NOT financial advice. All figures are delayed daily-close data from SEC EDGAR & market data, shown with their as-of date; "Edge" cells are a pure numeric comparison, not a recommendation.