DNLI vs IONS
DNLI: Denali Therapeutics is a clinical-stage biotechnology company developing blood-brain barrier-penetrating therapeutics to treat neurodegenerative and lysosomal storage diseases. IONS: Ionis Pharmaceuticals is a pioneer in RNA-targeted therapies, transitioning into a commercial-stage biotech with a pipeline focused on neurology and cardiometabolic diseases.
Side-by-side fundamentals
| Metric | DNLI | IONS | Edge |
|---|---|---|---|
| Price as of 2026-10-08 close | $18.67 | $43.30 | |
| Market cap | $3.0B | $7.2B | |
| Net margin FY2025, SEC XBRL | n/a | -40.4% | |
| Operating margin FY2025, SEC XBRL | n/a | -40.4% | |
| ROE FY2025, SEC XBRL | -50.6% | -78.0% | DNLI higher |
| ROA FY2025, SEC XBRL | -44.8% | -10.8% | IONS higher |
| Debt / equity as of 2026-09-03 | 0.01 | 4.35 | DNLI lower |
| Revenue growth (YoY) as of 2026-09-02 | n/a | -7.5% | |
| Revenue CAGR (3y) SEC XBRL | n/a | +17.1% | |
| Dividend streak (yrs) SEC XBRL | 0 | 0 | Tie |
| Beta as of 2026-09-03 | 1.46 | 0.70 | |
| 1-year return as of 2026-10-08 close | +19.3% | -38.1% | DNLI higher |
Fundamentals: SEC XBRL company filings for the figures marked with a fiscal year, and market data, as of 2026-09-03 for the rest. Filings: SEC EDGAR. Prices are delayed daily-close data.
Last updated 2026-10-08.
Informational only — NOT financial advice. All figures are delayed daily-close data from SEC EDGAR & market data, shown with their as-of date; "Edge" cells are a pure numeric comparison, not a recommendation.