LLY vs SYRE
LLY: Eli Lilly is a global pharmaceutical innovator leading the market in metabolic health, including diabetes and obesity treatments, alongside a diverse portfolio of oncology and immunology therapies. SYRE: Spyre Therapeutics is developing next-generation, extended half-life antibodies and combination therapies aimed at redefining the standard of care for inflammatory bowel disease and immune-mediated conditions.
Side-by-side fundamentals
| Metric | LLY | SYRE | Edge |
|---|---|---|---|
| Price as of 2026-10-08 close | $1,169.60 | $79.90 | |
| Market cap | $1.10T | $7.0B | |
| P/E as of 2026-10-08 | 39.25 | n/a | |
| PEG as of 2026-10-08, 3-year EPS CAGR to FY2025 | 0.80 | n/a | |
| Net margin FY2025, SEC XBRL | +31.7% | n/a | |
| ROE FY2025, SEC XBRL | +77.8% | -21.7% | LLY higher |
| ROA FY2025, SEC XBRL | +18.4% | -20.0% | LLY higher |
| Debt / equity as of 2026-09-03 | 1.62 | 0.00 | SYRE lower |
| Revenue growth (YoY) as of 2026-09-03 | +49.6% | n/a | |
| Revenue CAGR (3y) SEC XBRL | +31.7% | n/a | |
| Dividend yield as of 2026-09-03 | +0.6% | n/a | |
| Dividend streak (yrs) SEC XBRL | 10 | 0 | LLY higher |
| Beta as of 2026-09-03 | 0.55 | 1.71 | |
| 1-year return as of 2026-10-08 close | +38.3% | +351.9% | SYRE higher |
Fundamentals: SEC XBRL company filings for the figures marked with a fiscal year, and market data, as of 2026-09-03 for the rest. Filings: SEC EDGAR. Prices are delayed daily-close data.
Last updated 2026-10-08.
Informational only — NOT financial advice. All figures are delayed daily-close data from SEC EDGAR & market data, shown with their as-of date; "Edge" cells are a pure numeric comparison, not a recommendation.