SION vs VRTX
SION: Sionna Therapeutics is a clinical-stage biopharma company pioneering NBD1-stabilizing therapies to treat the underlying cause of cystic fibrosis. VRTX: Vertex is a leader in biotechnology primarily recognized for its dominance in cystic fibrosis therapy and its emerging pipeline of gene-editing treatments and non-opioid pain relief.
Side-by-side fundamentals
| Metric | SION | VRTX | Edge |
|---|---|---|---|
| Price as of 2026-10-08 close | $4.90 | $503.25 | |
| Market cap as of 2026-07-31 (share count; price 2026-10-08) | $222M | $127.6B | |
| P/E as of 2026-10-08 | n/a | 29.28 | |
| Net margin FY2025, SEC XBRL | n/a | +32.9% | |
| Operating margin FY2025, SEC XBRL | n/a | +34.8% | |
| ROE FY2025, SEC XBRL | -24.5% | +21.2% | VRTX higher |
| ROA FY2025, SEC XBRL | -23.1% | +15.4% | VRTX higher |
| Debt / equity as of 2026-09-02 | 0.00 | 0.00 | Tie |
| Revenue growth (YoY) as of 2026-09-02 | n/a | +10.2% | |
| Revenue CAGR (3y) SEC XBRL | n/a | +10.4% | |
| Dividend streak (yrs) SEC XBRL | 0 | 0 | Tie |
| Beta as of 2026-09-02 | 0.94 | 0.47 | |
| 1-year return as of 2026-10-08 close | -82.8% | +19.5% | VRTX higher |
Fundamentals: SEC XBRL company filings for the figures marked with a fiscal year, and market data, as of 2026-09-02 for the rest. Filings: SEC EDGAR. Prices are delayed daily-close data.
Last updated 2026-10-08.
Informational only — NOT financial advice. All figures are delayed daily-close data from SEC EDGAR & market data, shown with their as-of date; "Edge" cells are a pure numeric comparison, not a recommendation.