CYTOMX THERAPEUTICS INC (CTMX)
Health Care · biotechnology · NASDAQ
CytomX Therapeutics develops 'Probody' platform technology to engineer precision, tumor-activated antibody therapies designed to maximize cancer cell targeting while sparing healthy tissue.
What CYTOMX THERAPEUTICS INC does
CytomX Therapeutics is a clinical-stage biopharmaceutical company focused on developing a novel class of antibody-based cancer therapeutics. Its proprietary platform, Probody, designs therapeutic antibodies that are masked to remain inactive in healthy tissue and activated only within the tumor microenvironment, aiming to improve the safety and efficacy of cancer treatments.
Themes: oncology / cancer therapy, precision medicine, antibody engineering, biotechnology platform
Fundamentals
- Price$2.47 as of 2026-10-08 close
- Market cap$538M as of 2026-07-31 (share count; price 2026-10-08)
- 1-year return-26.7% 2025-10-08 close $3.37 → 2026-10-08 close $2.47
- P/En/a negative earnings
- Net margin-22.8% FY2025, SEC XBRL
- ROE-17.5% FY2025, SEC XBRL
- Debt / equity0.00 as of 2026-09-03
- Revenue growth (YoY)-87.0% as of 2026-09-03
- Revenue CAGR (3y)+12.8% SEC XBRL
- Beta1.32 as of 2026-09-03
- Last reported earnings2026-08-06 SEC EDGAR Form 8-K (Item 2.02)
How CTMX compares in its sector
- net profit marginmiddle range 430 covered Health Care peers, as of 2026-09-03
- operating marginmiddle range 417 covered Health Care peers, as of 2026-09-03
- return on equitymiddle range 510 covered Health Care peers, as of 2026-09-03
- 3-year revenue CAGRmiddle range 402 covered Health Care peers
- free cash flow (absolute dollars, latest fiscal year)middle range 494 covered Health Care peers, as of FY2025
Position among covered Health Care companies that report each metric (minimum 5 peers). A relative position within our covered catalog — not a valuation, quality, or investment judgment. A higher percentile is simply a higher value (for P/E, more expensive on earnings — never "better"). Informational only.
How CYTOMX THERAPEUTICS INC looks technically
CYTOMX THERAPEUTICS INC (CTMX) is trading 38.8% below its 200-day average, the long-term trend line — a long-term downtrend. Its 50-day average crossed below its 200-day average about 82 trading days ago — a "death cross", a bearish long-term signal. A strong downtrend is in place — ADX, a 0–100 trend-strength gauge, is 29, with sellers in control. Momentum is beaten down — its 14-day RSI (a 0–100 momentum gauge) is 30, in oversold territory (below 30). It just made a new 20-day low, its first since 2025-09-24, breaking below its recent trading range. It is 1.6% above its 52-week low (its lowest price of the past year).
Trend
7
| Distance from the 200-day | it is trading 38.8% below its 200-day average, the long-term trend line — a long-term downtrend | -38.8% |
|---|---|---|
| 50-day moving average | its average price over the last 50 trading days — a short-term trend line — is $3.15 | $3.15 |
| 200-day moving average | its average price over the last 200 trading days — the long-term trend line — is $4.03 | $4.03 |
| Swing structure | its recent peaks and dips disagree — one of them is rising while the other is not, so there is no clean up or down pattern in the swings | mixed — one of the two is not confirming |
| Last swing turn | its last significant turn was a swing low 23 calendar days ago — the swings before that are what the structure reading is measured on | 23 sessions |
| Since the 50/200 cross | its 50-day average crossed below its 200-day average about 82 trading days ago — a "death cross", a bearish long-term signal | 82 sessions |
| Trend strength (14-day ADX) | a strong downtrend is in place — ADX, a 0–100 trend-strength gauge, is 29, with sellers in control | 28.5 |
Momentum
3
| 14-day RSI | momentum is beaten down — its 14-day RSI (a 0–100 momentum gauge) is 30, in oversold territory (below 30) | 29.8 |
|---|---|---|
| Position in its 14-day range | it is trading near the bottom of its 14-day range ($2.43 to $3.00) — its "stochastic" reading is 7 out of 100, where 0 would mean closing exactly at the 14-session low and 100 exactly at the high. This measures WHERE the price sits inside its recent range, which is a different question from the RSI beside it: RSI is a momentum gauge, measuring how FAST the price has been moving, so a stock can drift quietly to the bottom of its range with an ordinary RSI, or fall sharply and still sit in the middle. It has been slipping within that range over the last few sessions. | 7.1 |
| Since the MACD crossed zero | MACD, a trend-momentum gauge, is in negative territory (momentum leaning bearish) | 20 sessions |
Range
12
| 52-week high | its highest closing price over the past year (about 252 trading days) was $8.20 | $8.20 |
|---|---|---|
| From the 52-week high | it is 69.9% below its 52-week high (its highest price of the past year) | -69.9% |
| Above the 52-week low | it is 1.6% above its 52-week low (its lowest price of the past year) | +1.6% |
| Below the 52-week high | it is 69.9% below its highest point of the past year | 69.9% |
| Since a 20-day breakout | it just made a new 20-day low, its first since 2025-09-24, breaking below its recent trading range | 1 session |
| Since a 55-day breakout | it just made a new 55-day low, its first since 2025-09-24, breaking below its recent trading range | 1 session |
| All-time high | its highest closing price on record is $35.00 (set on 2018-03-08) | $35.00 |
| Given back of the 52-week move | over the past year its closes ranged ($2.47 to $6.75), and it has recovered essentially none of its fall from last year’s high — 0% of it. Chart-watchers call 61.8%-65% given back the "golden pocket" — for this company that is $5.12 to $5.25. It is watched widely enough that orders cluster there, which is the honest reason it matters; it is not a forecast. | 0.0% |
| From the all-time high | it is 92.9% below its all-time high | -92.9% |
| Nearest price level | it is trading 6.6% above a support level at $2.31 — a price it turned at twice since 2025-07-21, most recently on 2025-09-08. Since 2024-10-08 it has 4 such levels below the current price and 8 above. Levels like these describe where the price has reversed or paused before; they are not a forecast of where it will go. | -6.6% |
| All-time low | its lowest closing price on record is $0.4 (set on 2025-04-07) | $0.4 |
| Above the all-time low | it is 517.5% above its all-time low | +517.5% |
Volatility
5
| Band width vs its own 6 months | day-to-day price swings are about average versus its own recent 6-month history | 56th percentile |
|---|---|---|
| Typical daily range | in a typical session it travels about $0.1668 between its high and its low — about 6.8% of its price. That is its "average true range" over the last 14 sessions, which also counts the distance from the previous close, so a day that opens well away from yesterday counts as the large move it was | $0.1668 |
| Bollinger bands (20-day, ±2σ) | most of its recent trading has stayed between about $2.35 and $3.14 — the "Bollinger bands", a range drawn two standard deviations either side of its 20-day average price, which widens when the stock gets more volatile and narrows when it settles | $2.35 – $2.75 – $3.14 |
| Typical daily range (% of price) | its price moves about 6.8% in a typical session — more volatile than most companies we cover. This is the average gap between a session's high and low over the last 14 sessions, counting overnight moves, expressed against the current price so it can be compared with companies trading at any price | 6.8% |
| Stretch from the 200-day average | it is trading 9.4 daily ranges below its 200-day average price (38.8% below it in plain percentage terms) — a way of asking how far it has stretched from its own average in units of how far it normally moves in a day, so a calm company and a jumpy one can be compared on the same scale | 9.4 daily ranges below its 200-day average |
Volume
1
| Volume vs its 30-day average | trading volume is about normal versus its 30-day average | 1.17× |
|---|
Analyst
2
| Change in the average price target | analysts' average price target is unchanged from the prior reading | 0.0% |
|---|---|---|
| Change in the consensus rating | the analyst consensus rating is unchanged since the prior reading | unchanged |
Candlestick patterns
1
| Since a doji | 8 sessions ago it opened and closed at almost the same price after trading through a wider range — a "doji", the classic picture of buyers and sellers finishing the session level | 8 sessions ago |
|---|
Price gaps
3
| Gap at the open | it opened on 2026-10-08 1.6% below the previous session's close — an overnight gap, the part of the move that happened while the market was shut, and had not traded back through that level by the close | -1.6% |
|---|---|---|
| Open gap | it gapped 2.6% below the previous close 22 sessions ago and has not traded back through the level it left behind at 3.71 — an "unfilled gap", which describes a price range no trade has since crossed and is not a forecast that it will be crossed | -2.6% |
| Gap filled | a 3.6% gap up opened on 2026-09-22 has been "filled" 12 sessions ago — price traded back through the level the gap left behind, and it closed again during the very session that opened it | 12 sessions ago |
Price streaks
1
| Closing streak | it has closed lower 3 sessions in a row, a -4.26% move over the run — an unbroken run of down days, which describes what has already happened and says nothing about the next session | 3 sessions down |
|---|
Relative strength
4
| vs market, 1 month | over the past 1 month this stock lagged the market by 33.4 percentage points (the stock lost 32.3% while the market gained 1.0%) | -33.4% |
|---|---|---|
| vs market, 3 months | over the past 3 months this stock lagged the market by 39.3 percentage points (the stock lost 35.5% while the market gained 3.8%) | -39.3% |
| vs market, 6 months | over the past 6 months this stock lagged the market by 61.3 percentage points (the stock lost 43.9% while the market gained 17.5%) | -61.3% |
| vs market, 12 months | over the past 12 months this stock lagged the market by 41.7 percentage points (the stock lost 26.7% while the market gained 15.0%) | -41.7% |
Signal agreement
2
| Bullish technical signals | 2 of the 9 technical signals we can compute for it are currently in a bullish state: its RSI momentum gauge is oversold (a beaten-down reading), near the bottom of its 14-day range (oversold) — these describe past price behaviour, not a forecast | 2 of 9 |
|---|---|---|
| Bearish technical signals | 7 of the 9 technical signals we can compute for it are currently in a bearish state: a "death cross" — its 50-day average is below its 200-day, trading below its 200-day average, a fresh 20-day low, MACD momentum is negative, a strong downtrend, with sellers in control, lagging the market over 6 months, trading below the Ichimoku cloud — these describe past price behaviour, not a forecast | 7 of 9 |
Trend (Ichimoku cloud)
1
| Vs the Ichimoku cloud | trading 28% below the Ichimoku cloud — a band drawn from where its own highs and lows sat up to 2026-09-01 and projected forward over today's price, the side traders read as an established downtrend, with the band above acting as the level that would have to be cleared. The band itself is thin, spanning 1.6% of the share price, which is taken to mean a barrier that gives way easily. | -27.6% |
|---|
Volume-weighted price
2
| Vs this year’s average price paid | the price is 44% below the average price paid so far this year, so the typical buyer over that stretch is under water. That average is $4.41 — a volume-weighted average of daily closes over 191 sessions, not a true tick-by-tick VWAP. | -44.0% |
|---|---|---|
| Vs the average paid since it last reported | the price is 20% below the average price paid since it last reported on 2026-08-06 (its 10-Q), so the typical buyer over that stretch is under water. That average is $3.10 — a volume-weighted average of daily closes over 45 sessions, not a true tick-by-tick VWAP. | -20.3% |
Price levels it has turned at before
CTMX last closed at $2.47 on 2026-10-08. Since 2024-10-08 it has turned at 4 prices below its last close and 8 above; the 3 nearest below and the 3 nearest above are listed, nearest first.
| Level | Side | Distance | Evidence |
|---|---|---|---|
| $2.31 | Support | 6.6% below the last close | turned there twice · 2025-07-21 to 2025-09-08 |
| $3.04 | Resistance | 23.0% above the last close | turned there twice · 2025-10-10 to 2026-08-03 |
| $3.42 | Resistance | 38.6% above the last close | turned there twice · 2025-11-18 to 2026-05-19 |
| $3.58 | Resistance | 44.7% above the last close | turned there twice · 2026-08-07 to 2026-08-19 |
| $1.17 | Support | 52.8% below the last close | turned there twice · 2024-11-08 to 2025-01-06 |
| $0.9841 | Support | 60.2% below the last close | turned there twice · 2024-10-29 to 2025-02-06 |
A level is a price this company reversed or paused at more than once — they describe past behaviour, not a forecast of where the price will go.
Wave structure
No Elliott-wave labelling currently fits its swings: the recent highs and lows do not satisfy the three rules a five-wave count has to obey, so there is no count to show rather than a count we are unsure about.
Read from daily closes as of 2026-10-08.
An Elliott-wave count describes the swings already printed and the level that would disprove it. It is not a forecast, a target, or advice.
Screens: Trading below the 200-day moving average · Oversold (14-day RSI below 30) · Near the 52-week low · Pulled back from the 12-month high · Broke down to a new 20-day low · lagging the market | Learn: moving average · golden cross · adx · rsi · breakout · fifty two week high low
Based on daily closing prices as of 2026-10-08. Describes past price behavior only — informational, not financial advice.
Analyst consensus
- Consensus ratingStrong Buy (1.38 mean, 1=Strong Buy…5=Strong Sell) — 8 analysts
- Mean price target$12.25 range $6.00 – $16.00; median $12.00
Analyst estimates, as of 2026-10-08. These are third-party analyst opinions and price targets, aggregated — not a recommendation, prediction, or advice from stocks-llm. Informational only.
Analyst EPS estimate for CTMX
- Consensus EPS estimate-$0.07076 next reporting period, as of 2026-10-08
- Estimate change, 30 days$0.00 from -$0.07076, on 2026-09-03, 35-day window
- Readings revised upward0% of 8 comparable readings
The consensus estimate for the next reporting period, and how it has moved between readings of that SAME period. A change is measured only between readings estimating one period — when a company reports, the consensus moves to the next quarter and the two numbers are not comparable. Informational only, not a forecast and not advice.
Key risks (from latest filing)
["The company is unprofitable and has a history of losses, with a reliance on collaborative agreements and capital raises to fund operations.","Development of novel therapeutic platforms is subject to high failure rates in clinical trials and regulatory uncertainty.","The company faces intense competition from established pharmaceutical companies and biotechnology firms with greater resources."]
What changed in the latest 10-Q
AI-assisted comparison of CTMX's 10-Q filed 2026-08-06 against the prior one filed 2026-05-07.
Management's Discussion & Analysis (MD&A)
- Added:
- Newer filing (2026-08-06) states Varseta-M doses to be assessed in combination with bevacizumab include Q2W and Q4W schedules to align with the approved bevacizumab CRC dose.
- Reworded:
- Newer filing (2026-08-06) changed 'pre-clinical stage programs' to 'preclinical stage programs'.
- Newer filing (2026-08-06) changed '(e.g., ADC, TCE)' to '(e.g., ADC, TCE)' with different punctuation style (changed 'e.g. ADC, TCE' to 'e.g., ADC, TCE').
- Newer filing (2026-08-06) removed 'are in Phase 1 clinical development and' from the description of the two clinical programs (Varseta-M and CX-801).
- Newer filing (2026-08-06) changed 'and discontinued' to 'and were discontinued'.
- Newer filing (2026-08-06) removed the '®' symbol after 'KORJUNY' in the second mention.
- Newer filing (2026-08-06) changed 'but is initially focused in CRC which' to 'but our current development had been initially focused in CRC, which'.
- Newer filing (2026-08-06) changed '5 year' to '5-year'.
- Newer filing (2026-08-06) changed 'is initially being focused on' to 'has primarily been focused on'.
- Newer filing (2026-08-06) changed 'While Varseta-M is initially being developed in late-line metastatic CRC' to 'While Varseta-M has initially been developed in late-line metastatic CRC'.
- Newer filing (2026-08-06) changed 'progress this vision to move Varseta-M' to 'progress this vision of moving Varseta-M'.
- Newer filing (2026-08-06) changed 'and initiated a Phase 1 combination study' to 'and we therefore initiated a Phase 1 combination study'.
- Notes:
- The newer filing text is truncated mid-sentence at the end of the provided excerpt.
- The older filing text is also truncated mid-sentence at the end of the provided excerpt, so changes after that point cannot be assessed.
Risk Factors
The two filings could not be meaningfully compared for this section.
AI-assisted comparison of two SEC filing sections. It describes wording and theme changes only, makes no materiality, legal, or investment judgement, and is not financial advice. Informational only — not financial advice.
Insider activity (SEC Form 4)
No open-market insider purchases or sales recorded in the last 90 days, of which we have read Form 4 filings through 2026-10-04. The 5 days since 2026-10-04 have not been checked yet.
- Last 180 days · read to 2026-10-040 buys · 1 sell ($4953) — 1 selling insider
Most recent open-market transaction: 2026-06-15. Based on Form 4 filings read through 2026-10-04; anything filed since is not yet included.
View full insider trading history → View SEC Form 3/4/5 filingsAsk about CTMX's insider activity →
Only open-market purchases (SEC code P) and sales (code S) are counted here. Option exercises, vesting/awards, gifts, and shares withheld for taxes are excluded — they are compensation or mechanical, not open-market conviction. Sales may be planned and non-discretionary (e.g. a Rule 10b5-1 plan) and are not necessarily bearish; open-market buying is not a recommendation to buy. Informational only — not financial advice.
Institutional ownership (13F)
4 institutional 13F filers reported holding CTMX as of 2026-06-30 (quarter-end position, filed within 45 days).
- Distinct 13F filers 4
- Reported shares held 68,682,213
- Reported value $257,558,300
reported quarterly holdings change (2026-03-31 → 2026-06-30): 0 new, 4 increased, 0 decreased, 0 exited. Change counts cover only managers that filed 13F reports in BOTH quarters, derived between two quarter-end snapshots — not same-day trades; a single manager is never said to have "bought" or "sold".
Institutional holdings are quarter-end long positions reported on SEC Form 13F-HR, filed up to 45 days after the quarter ends — they are delayed, are not real-time trades, exclude short positions and most non-US securities, and are not investment advice. Any increase/decrease is a reported change between two quarterly snapshots, not a same-day purchase or sale. These are quarter-end snapshots from the 13F filings on SEC EDGAR, filed within 45 days — not real-time, and any change is a difference between two quarterly reports, not a same-day trade. Informational only — not financial advice.
Ask about CTMX's institutional holders → See what each manager we track holds →
Short interest (FINRA)
CTMX had 38,639,220 shares of reported short interest as of the 2026-09-15 FINRA settlement date (delayed, bi-monthly; not real-time).
CTMX had 17.7% of its shares outstanding sold short as of the 2026-09-15 FINRA settlement date (percent of FLOAT would be higher — float is not disclosed in the source). FINRA reported 9.29 days to cover at the same settlement.
- Reported short interest (shares) 38,639,220
- Short interest (% of shares outstanding) 17.7%
- Prior settlement (shares) 33,512,293
- Reported change 15.3%
- Days to cover (reported) 9.29
Reported to FINRA as of the 2026-09-15 settlement date. Short interest is reported to FINRA and published on a delayed, bi-monthly schedule (as of a settlement date, disseminated roughly eight business days later) — it is NOT real-time, does not cover every venue or all US trading, and is not a short-squeeze prediction or investment advice. Days-to-cover is the value FINRA reports; percent of float is not shown because the source file carries no share-count denominator — where a percent appears it is of shares OUTSTANDING, the larger base, and is therefore a floor on percent of float. Informational only — not financial advice.
Competitors & peers
- Amgen (AMGN)
- Bristol-Myers Squibb (BMY)
- AstraZeneca (AZN)
- Gilead Sciences (GILD)
- Regeneron Pharmaceuticals (REGN)
- Seattle Genetics (Seagen - now Pfizer)
AI-enriched competitor set. Linked names are companies covered by stocks-llm; other named peers are shown for reference only.
Compare CTMX vs…
CYTOMX THERAPEUTICS INC is found in…
Frequently asked questions
What does CYTOMX THERAPEUTICS INC (CTMX) do?
CytomX Therapeutics is a clinical-stage biopharmaceutical company focused on developing a novel class of antibody-based cancer therapeutics. Its proprietary platform, Probody, designs therapeutic antibodies that are masked to remain inactive in healthy tissue and activated only within the tumor microenvironment, aiming to improve the safety and efficacy of cancer treatments.
What sector is CYTOMX THERAPEUTICS INC (CTMX) in?
CYTOMX THERAPEUTICS INC (CTMX) is classified in the Health Care sector. Its industry is biotechnology. It trades on NASDAQ.
Who are CYTOMX THERAPEUTICS INC's (CTMX) competitors?
Notable peers of CYTOMX THERAPEUTICS INC (CTMX) include Amgen, Bristol-Myers Squibb, AstraZeneca, Gilead Sciences and Regeneron Pharmaceuticals. This peer set is informational only — not financial advice.
Is CYTOMX THERAPEUTICS INC (CTMX) overbought or oversold right now?
CYTOMX THERAPEUTICS INC (CTMX) is currently in oversold territory (its 14-day RSI is 30, below 30) (as of 2026-10-08). RSI describes recent price momentum, not a forecast — informational only, not financial advice.
Where does stocks-llm's data on CTMX come from?
Fundamentals come from SEC XBRL company filings for the figures marked with a fiscal year, and market data, as of 2026-09-03 for the rest; prices are market data, as of 2026-09-03; company filings and profile facts come from SEC EDGAR. All figures are delayed daily-close data shown with their as-of date — informational only, not financial advice.
Fundamentals: SEC XBRL company filings for the figures marked with a fiscal year, and market data, as of 2026-09-03 for the rest. Filings: SEC EDGAR. Prices are delayed daily-close data.
Last updated 2026-10-08.
Informational only — NOT financial advice. All figures are delayed daily-close data from SEC EDGAR & market data, shown with their as-of date.